H2N2V1, Main, Exploration, bibRecord, 002B61

Replication of influenza virus in organ cultures of human and simian urogenital tissues and human foetal tissues.

Identifieur interne : 002B61 ( Main/Exploration ); précédent : 002B60; suivant : 002B62

Replication of influenza virus in organ cultures of human and simian urogenital tissues and human foetal tissues.

Auteurs : I. Roszt Czy ; C. Sweet ; G. L. Toms ; H. Smith

Source :

British Journal of Experimental Pathology [ 0007-1021 ] ; 1975.

RBID : PMC:2072765

Descripteurs français

KwdFr :
- Animaux, Appareil urogénital (microbiologie), Complications de la grossesse et maladies infectieuses (étiologie), Culture virale, Femelle, Foetus, Grippe humaine (étiologie), Grossesse, Haplorhini, Humains, Macaca, Maladies foetales (étiologie), Orthomyxoviridae (croissance et développement), Orthomyxoviridae (immunologie), Papio, Réplication virale, Techniques de culture.
MESH :
- croissance et développement : Orthomyxoviridae.
- immunologie : Orthomyxoviridae.
- microbiologie : Appareil urogénital.
- étiologie : Complications de la grossesse et maladies infectieuses, Grippe humaine, Maladies foetales.
- Animaux, Culture virale, Femelle, Foetus, Grossesse, Haplorhini, Humains, Macaca, Papio, Réplication virale, Techniques de culture.

English descriptors

KwdEn :
- Animals, Culture Techniques, Female, Fetal Diseases (etiology), Fetus, Haplorhini, Humans, Influenza, Human (etiology), Macaca, Orthomyxoviridae (growth & development), Orthomyxoviridae (immunology), Papio, Pregnancy, Pregnancy Complications, Infectious (etiology), Urogenital System (microbiology), Virus Cultivation, Virus Replication.
MESH :
- etiology : Fetal Diseases, Influenza, Human, Pregnancy Complications, Infectious.
- growth & development : Orthomyxoviridae.
- immunology : Orthomyxoviridae.
- microbiology : Urogenital System.
- Animals, Culture Techniques, Female, Fetus, Haplorhini, Humans, Macaca, Papio, Pregnancy, Virus Cultivation, Virus Replication.

Abstract

A survey of human adult tissues in organ cultures showed that influenza viruses (A/Moscow/1019/65 (h2n2) or a recombinant virus virulent for man (PR/8-A/England/939/69 Clone 7a(H3N2)) could infect uterus, bladder and conjunctiva but not oesophagus under the conditions employed; simian bladder and uterus were also susceptible. These results were similar to those already described for corresponding ferret tissues. Organ cultures of human foetal nasal mucosa, trachea, oesophagus, small and large intestine, and bladder consistently supported replication over 4 days or more with high virus yields. Lung, conjunctiva and umbilical cord were less consistently susceptible and gave lower yields. Placenta and kidney cultures allowed replication of virus in one of 8 and one of 4 experiments respectively, the yields being low and of short duration. Organ cultures of neural tissue (meninges and brain), lymphopoietic tissue (spleen, liver and thymus) and amnion did not support significant viral replication. The results are discussed in relation to possible infection of the foetus in utero with influenza virus.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2072765

PubMed: 809051
PubMed Central: 2072765

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en"><p>A survey of human adult tissues in organ cultures showed that influenza viruses (A/Moscow/1019/65 (h2n2) or a recombinant virus virulent for man (PR/8-A/England/939/69 Clone 7a(H3N2)) could infect uterus, bladder and conjunctiva but not oesophagus under the conditions employed; simian bladder and uterus were also susceptible. These results were similar to those already described for corresponding ferret tissues. Organ cultures of human foetal nasal mucosa, trachea, oesophagus, small and large intestine, and bladder consistently supported replication over 4 days or more with high virus yields. Lung, conjunctiva and umbilical cord were less consistently susceptible and gave lower yields. Placenta and kidney cultures allowed replication of virus in one of 8 and one of 4 experiments respectively, the yields being low and of short duration. Organ cultures of neural tissue (meninges and brain), lymphopoietic tissue (spleen, liver and thymus) and amnion did not support significant viral replication. The results are discussed in relation to possible infection of the foetus in utero with influenza virus.</p>
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Replication of influenza virus in organ cultures of human and simian urogenital tissues and human foetal tissues.

Replication of influenza virus in organ cultures of human and simian urogenital tissues and human foetal tissues.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

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